Buclizine HCl: Increased possibility for toxicity w/ alcohol & other CNS depressants including hypnotics, sedatives, tranquilizers, anti-anxiety agents & narcotic analgesics. Prolonged & intensified anticholinergic effect w/ MAOIs (eg, amitriptyline, imipramine, sertraline, moclobemide). Fe: Decreased absorption w/ antacids (take at least 1 hr before) & tetracyclines (take at least 1 hr before & 3 hr after). Delayed response to Fe therapy w/ chloramphenicol. May decrease absorption & reduce bioavailability of carbidopa, levodopa, methyldopa & penicillamine.